Medicinal Chemistry

Organisational unit: Research Group

  1. 2016
  2. 2012
  3. 2010
  4. 2007
  5. Finnema, S. J., Bang-Andersen, B., Jorgensen, M., Jogolev, G., Gulyas, B., Farde, L., ... Halldin, C. (2007). COMT inhibition is a method for avoidance of lipophilic radiometabolites of catechols, exemplified with (S)-[C-11]N-methyl-NNC 01-0259. European Journal of Nuclear Medicine and Molecular Imaging, 34, S205-S206.
  6. 2006
  7. 2005
  8. Finnema, S. J., Seneca, N., Farde, L., Gulyas, B., Bang-Andersen, B., Wikstrom, H. V., ... Halldin, C. (2005). Scatchard Analysis of the D2 Receptor Agonist [C-11]MNPA in the Monkey Brain Using PET. European Journal of Nuclear Medicine and Molecular Imaging, 32, S82-S82.
  9. Lu, S. Y., Liow, J. S., Zoghbi, S. S., Brown, A. K., Musachio, J. L., Vermeulen, E. S., ... Pike, V. W. (2005). Synthesis and preliminary evaluation of [F-18] S14506 as a novel PET radioligand for brain 5-HT1A receptors in rat. European Journal of Nuclear Medicine and Molecular Imaging, 32, S52-S52.
  10. Lu, S. Y., Liow, J. S., Ichise, M., Hong, J., Musachio, J. L., Zoghbi, S. S., ... Pike, V. W. (2005). EVALUATION OF [O-METHYL-C-11]S14506 AS AN AGONIST RADIOLIGAND FOR BRAIN 5-HT1A RECEPTORS IN RAT AND MONKEY. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 48, S72-S72.
  11. McCarron, J. A., Zoghbi, S. S., Liow, J. S., Hong, J., Lu, S. Y., Vermeulen, E. S., ... Pike, V. W. (2005). 5-HT1A RECEPTOR IMAGING WITH [C-11](S)-RWAY IN RAT BRAIN SHOWS A STRIKING DIFFERENCE IN PGP EFFECT COMPARED TO IMAGING IN MONKEY. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 48, S73-S73.
  12. Oberwinkler - Marchais, S., Nowicki, B., Pike, V. W., Halldin, C., Sandell, J., Chou, Y. H., ... Wikstrom, H. V. (2005). N-Oxide analogs of WAY-100635: new high affinity 5-HT (1A) receptor antagonists. Bioorganic & Medicinal Chemistry, 13(3), 883-893. DOI: 10.1016/j.bmc.2004.10.033
  13. Finnema, S. J., Seneca, N., Farde, L., Shchukin, E., Gulyas, B., Wikström, H. V., ... Halldin, C. (2005). A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey. Nuclear Medicine and Biology, 32, 353 - 360.
  14. McCarron, J. A., Marchais-Oberwinkler, S., Pike, V. W., Tarkiainen, J., Halldin, C., Sovago, J., ... Marchais-Overwinkler, S. (2005). Two C-methyl derivatives of [C-11]WAY-100635 - Effects of an amido alpha-methyl group on metabolism and brain 5-HT1A receptor radioligand behavior in monkey. Molecular Imaging and Biology, 7(3), 209-219. DOI: 10.1007/s11307-005-4127-5
  15. 2004
  16. Farde, L., Seneca, N., Finnema, S. J., Wikstrom, H. V., & Halldin, C. (2004). The dopamine hypothesis of schizophrenia: The role of pet. International Journal of Neuropsychopharmacology, 7, S67-S67.
  17. Vermeulen, E. S., van Smeden, M., Schmidt, A. W., Sprouse, J. S., Wikström, H. V., & Grol, C. (2004). Novel 5-HT7receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides. Journal of Medicinal Chemistry, 47(22), 5451 - 5466.
  18. McCarron, J. A., Pike, V. W., Halldin, C., Sandell, J., Sovago, J., Gulyas, B., ... Farde, L. (2004). The pyridinyl-6 position of WAY-100635 as a site radiofluorination--effect on 5-HT1A receptor radioligand behavior in vivo. Molecular Imaging and Biology, 6(1), 17 - 26. DOI: 10.1016/j.mibio.2003.12.001
  19. 2003
  20. Venhuis, B. J., Dijkstra, D., Wustrow, D., Meltzer, L. T., Wise, L. D., Johnson, S. J., & Wikström, H. V. (2003). Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-Di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity. Journal of Medicinal Chemistry, 46(19), 4136-4140. DOI: 10.1021/jm0307786
  21. Venhuis, B. J., Dijkstra, D., Wustrow, D. J., Meltzer, L. T., Wise, L. D., Johnson, S. J., ... Wikstrom, H. V. (2003). Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one: Synthesis and pharmacological activity. Journal of Medicinal Chemistry, 46(4), 584-590. DOI: 10.1021/jm020990u
  22. 2002
  23. Dijkstra, D., Rodenhuis, N., Vermeulen, E. S., Pugsley, T. A., Wise, L. D., & Wikstrom, H. V. (2002). Further characterization of structural requirements for ligands at the dopamine D-2 and D-3 receptor: Exploring the thiophene moiety. Journal of Medicinal Chemistry, 45(14), 3022-3031. DOI: 10.1021/jm001015a
  24. Pike, . N. V., Tarkiainen, J., Marchais, S., McCarron, J., Halldin, C., Sovago, J., ... Farde, L. (2002). Evaluation of two C-methyl derivatives of C-11-WAY-100635 as potential radioligands for 5-HT1A receptors. Journal of Nuclear Medicine, 43(5), 359P-360P. [200687].
  25. 2001
  26. McCarron, J. A., Sandell, J., Pike, V. W., Halldin, C., Gulyas, B., Cselenyi, Z. S., ... Farde, L. (2001). (18)F6FPWAY-synthesis and initial investigation as a prospective 5-HT1A receptor radioligand in vivo. Journal of Nuclear Medicine, 42(5), 251P-251P.
  27. Mouithys-Mickalad, A., Kauffmann, J. M., Petit, C., Bruhwyler, J., Liao, Y., Wikstrom, H., ... Liegeois, J. F. (2001). Electrooxidation potential as a tool in the early screening for new safer clozapine-like analogues. Journal of Medicinal Chemistry, 44(5), 769-776. DOI: 10.1021/jm000221f
  28. 2000
  29. van Vliet, L. A., Rodenhuis, N., Wikström, H. V., Pugsley, T. A., Serpa, K. A., Meltzer, L. T., ... Bast, A. (2000). Thiazoloindans and thiazolobenzopyrans: A novel class of orally active central dopamine (partial) agonists. Journal of Medicinal Chemistry, 43(19), 3549-3557. DOI: 10.1021/jm000087z
  30. 1999
  31. Liao, Y., Venhuis, B. J., Rodenhuis, N., Timmerman, W., Wikstrom, H., Meier, E., ... Sundell, S. (1999). New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: Chemistry and pharmacological evaluation. Journal of Medicinal Chemistry, 42(12), 2235-2244. DOI: 10.1021/jm991005d
  32. 1998
  33. 1992
  34. 1986
  35. 1977
  36. 1975
  37. 1974

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