Publication

Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands

van Zanten, A., Arends, S., Roozendaal, C., Limburg, P. C., Maas, F., Trouw, L. A., Toes, R. E. M., Huizinga, T. W. J., Bootsma, H. & Brouwer, E. Jul-2017 In : Annals of the Rheumatic Diseases. 76, 7, p. 1184-1190 7 p.

Research output: Scientific - peer-reviewArticle

Documents

DOI

Objectives To determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the general population.

Methods Lifelines is a multidisciplinary prospective population-based cohort study in the Netherlands. Cross-sectional data from 40 136 participants were used. The detection of ACPA was performed by measuring anti-CCP2 on the Phadia-250 analyser with levels >= 6.2 U/mL considered positive. An extensive questionnaire was taken on demographic and clinical information, including smoking, periodontal health and early symptoms of musculoskeletal disorders. RA was defined by a combination of self-reported RA, medication use for the indication of rheumatism and visiting a medical specialist within the last year.

Results Of the total 40 136 unselected individuals, 401 (1.0%) had ACPA level >= 6.2 U/mL. ACPA positivity was significantly associated with older age, female gender, smoking, joint complaints, RA and first degree relatives with rheumatism. Of the ACPA-positive participants, 22.4% had RA (15.2% had defined RA according to our criteria and 7.2% self-reported RA only). In participants without RA, 311 (0.8%) were ACPA-positive. In the non-RA group, older age, smoking and joint complaints remained significantly more frequently present in ACPA-positive compared with ACPA-negative participants.

Conclusions In this large population-based study, the prevalence of ACPA levels >= 6.2 U/mL was 1.0% for the total group and 0.8% when excluding patients with RA. Older age, smoking and joint complaints were more frequently present in ACPA-positive Lifelines participants. To our knowledge, this study is the largest study to date on ACPA positivity in the general, mostly Caucasian population.

Original languageEnglish
Pages (from-to)1184-1190
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume76
Issue number7
StatePublished - Jul-2017

    Keywords

  • RHEUMATOID-ARTHRITIS PATIENTS, CYCLIC CITRULLINATED PEPTIDE, UNAFFECTED 1ST-DEGREE RELATIVES, BLOOD-DONORS, RISK, AUTOANTIBODIES, ARTHRALGIA, SMOKING, WOMEN, RA

View graph of relations

ID: 43921171