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Food intake and darunavir plasma concentrations in people living with HIV in an outpatient setting

Daskapan, A., Dijkema, D., de Weerd, A., Bierman, W. F. W., Kosterink, J. G. W., van der Werf, T. S., Alffenaar, J. W. C. & Stienstra, Y. 7-Jul-2017 In : British Journal of Clinical Pharmacology.

Research output: Scientific - peer-reviewArticle

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DOI

Patients receiving darunavir are advised to take it concomitantly with food. The objectives of this study were to evaluate the actual concomitant food intake of patients visiting an HIV outpatient clinic. In this cross-sectional study participants treated with darunavir/ritonavir once daily were subjected to a food recall-questionnaire concerning their last concomitant food intake with darunavir. Darunavir trough concentrations were calculated. For the 60 participants the median food intake was 507 (0 - 2707) kcal; protein intake, 20 (0 - 221)g; carbohydrates, 62 (0 - 267)g; fat intake: 14 (0 - 143)g; and dietary fiber: 4 (0 - 30)g. Twenty-five patients (42%) ingested their drug with in-between meals. No relation was found between food intake and trough concentrations. Clear advice on the optimal caloric intake is needed to avoid high caloric intake in patients who already have an increased risk of cardiovascular disease due to their HIV infection.

Original languageEnglish
JournalBritish Journal of Clinical Pharmacology
StateE-pub ahead of print - 7-Jul-2017

    Keywords

  • Journal Article

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