Publication

Food intake and darunavir plasma concentrations in people living with HIV in an outpatient setting

Daskapan, A., Dijkema, D., de Weerd, D. A., Bierman, W. F. W., Kosterink, J. G. W., van der Werf, T. S., Alffenaar, J-W. C. & Stienstra, Y. Oct-2017 In : British Journal of Clinical Pharmacology. 83, 10, p. 2325-2329 5 p.

Research output: Scientific - peer-reviewArticle

AIMS

Patients receiving darunavir are advised to take it concomitantly with food. The objectives of the present cross-sectional study were to evaluate the actual concomitant food intake of patients visiting an HIV outpatient clinic.

METHODS

Sixty participants treated with darunavir/ritonavir once daily were subjected to a food recall questionnaire concerning their last concomitant food intake with darunavir. Darunavir trough concentrations were calculated.

RESULTS

The median food intake was 507 (0-2707) kcal; protein intake, 20 (0-221)g; carbohydrate intake, 62 (0-267)g; fat intake: 14 (0-143)g; and dietary fibre: 4 (0-30)g. Twenty-five patients (42%) ingested their drug with between-meal snacks. No relationship was found between food intake and trough concentrations.

CONCLUSIONS

Clear advice on the optimal caloric intake is needed, to avoid high caloric intake in patients who already have an increased risk of cardiovascular disease due to their HIV infection.

Original languageEnglish
Pages (from-to)2325-2329
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Volume83
Issue number10
Early online date7-Jul-2017
StatePublished - Oct-2017

    Keywords

  • ntiretrovirals, clinical pharmacology, HIV/AIDS, infectious diseases, patient safety, pharmacokinetics

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