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Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress

van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M-J., Haenen, G. R. M. M., Heijink, I. H., Rouschop, K. M. A., Dubois, L. J. & Lambin, P. 3-Aug-2017 In : Plos one. 12, 8, 13 p., 0182508

Research output: Scientific - peer-reviewArticle

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DOI

  • Marike W. van Gisbergen
  • An M. Voets
  • Rianne Biemans
  • Roland F. Hoffmann
  • Marie-Jose Drittij-Reijnders
  • Guido R. M. M. Haenen
  • Irene H. Heijink
  • Kasper M. A. Rouschop
  • Ludwig J. Dubois
  • Philippe Lambin

Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that radiation responsiveness will be enhanced in cellular models with decreased mtDNA content, attributed to altered reactive oxygen species (ROS) production and antioxidant capacity. For this purpose BEAS-2B, A549, and 143B cell lines were depleted from their mtDNA (rho(0)). Overall survival after irradiation was increased (p

Original languageEnglish
Article number0182508
Number of pages13
JournalPlos one
Volume12
Issue number8
StatePublished - 3-Aug-2017

    Keywords

  • MITOCHONDRIAL-DNA, SUPEROXIDE-DISMUTASE, IONIZING-RADIATION, SURVIVAL CURVES, TUMOR RESPONSE, CANCER CELLS, LUNG-CANCER, METABOLISM, ANTIOXIDANT, GENERATION

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ID: 47215817