Research interests

Liesbeth Marian Veenhoff

Born 23-11-1972, NL

Partner of Jan Jacob Schuringa, mother of two born 2003 and 2005

Address: European Research Inst. for the Biology of Ageing, University Medical Center Groningen; Antonius Deusinglaan 1; room 205, 9713 AV Groningen; The Netherlands

email: l.m.veenhoff@rug.nl

 

Training

Master: University of Groningen; August 1996; Biology (Biochemistry/Molecular Biology)

PhD: University of Groningen; 7 September 2001, supervisor Prof. Dr. Poolman; Cum Laude

 

Work experience since completing PhD

2002-2003           post doctoral HFSP fellow, Rockefeller University (New York, USA), 1fte

2004-2010           post doctoral veni & vidi fellow, University of Groningen (NL), 0.8fte

2010-2012           Assistant Prof, University Medical Center Groningen (NL), 1fte, tenure track   

2012-present       Group leader (UHD/Associate Prof since 2015), European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (NL), 1fte, tenure track continued

 

Brief summary of research over the last five years

My ambition is to understand molecular machines in the context of a cell: ‘how does a protein(complex) work’ or ‘what is it made of`, and also ´how was it sorted there’ or ‘how does it work together with other biomolecules’. My expertise is in biochemistry and cell biology, and in collaboration with experts I have also successfully explored molecular dynamics, biophysical and systems biology approaches.

Some highlights over the last years were:

  • In 2011 I published a paper in Science showing for the first time that a sorting signal for transport to the inner membrane consists of an NLS and a long intrinsically discorded linker. Follow up papers on the mechanism were published (Traffic 2013, Structure 2015) as well as a paper where we provide first evidence suggesting conservation in humans (Kralt et al., MBoC 2015).
  • My first PhD student was awarded a prize for the best thesis in biochemistry in the Netherlands in 2011.
  • Starting 3 years ago, I study replicative ageing in baker’s yeast. The topic of cellular ageing opened new directions for me, that coincided with the selection in 2012 of my group to join a new institute in Groningen, the European Research Institute for the Biology of Ageing (ERIBA). Using new methods for population based and single cell studies we generated a rich and exciting systems view on cellular ageing in yeast.
  • In 2014 we wrote two papers (BiohysJ. 2014, Popken et al., MBoC 2015) describing the development of a computational model of the Nuclear Pore Complex that faithfully predicts permeability of the NPC measured in vivo. The exact mechanism and the factors influencing permeability remain major unsolved questions which this combined modelling and in-vivo work helps resolve.

 

Grants, scholarships and prizes

PI   

2016 Aspasia, Netherlands Organization for Scientific Reserach (NWO)   

2015 'A mother’s sacrifice: asymmetric inheritance of ageing factors' Netherlands Organization for Scientific Reserach (NWO-ALW) 

2013 ‘Aging of the Nuclear Pore Complex: relating structure and function’ Netherlands Organization for Scientific Research (ECHO-NWO).               

2008 ‘Composition, function, and dynamics of the yeast nuclear envelope’ financed by the Netherlands Organization for Scientific Research (Vidi-NWO)        

2004 Veni-NWO 

2002 Human Frontiers Fellowship long term fellowship           

2001 My thesis 'Mechanistic aspects and structural organization of a secondary sugar transporter' was awarded with the honour 'Cum laude' representing the top 5 % of PhD theses.          

1996 The Unilever Research Award 1996 for the best master student research project ‘Purification and reconstitution of transport proteins’.             

Co-PI     

2010 Co-author on the proposal for the Systems Biology Centre for Energy Metabolism and Ageing. Funding for 1 PhD student, project leader. (NWO)    

2008 Co-author on collaborative project “transport through a polymer network”. Funding for 1 PhD student. (Zernike institute for Advanced Material)           

2008 The Netherlands Proteomics Centre funds proteome research on the yeast nucleus. Funding for 1 PhD student.      

Publications

  1. Protein biogenesis machinery is a driver of replicative aging in yeast

    Research output: Scientific - peer-reviewArticle

  2. The molecular architecture of the nuclear pore complex

    Research output: Scientific - peer-reviewArticle

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