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OnderzoekGBBMolecular Cell Biology

Molecular Cell Biology

Our group performs molecular cell biology research on organelles using yeast as model organisms. We mainly focus on the function, formation and degradation of peroxisomes, but we also study mitochondria, the endoplasmic reticulum and vacuoles.

Peroxisomes are very important cell organelles that occur in all eukaryotes. Their importance is stressed by the fact that peroxisome dysfunction in man is lethal. The organelles play important roles in hydrogen peroxide metabolism and fatty acid oxidation. However, dependent on the organism and developmental stage, a large number of additional metabolic and biosynthetic functions can occur in peroxisomes. An important example is the biosynthesis of the antibiotic penicillin in peroxisomes of filamentous fungi.

The research is multi-disciplinary, combining molecular, biochemical and physiological approaches, together with the use of various microscopy techniques such as electron microscopy, fluorescence microscopy and confocal laser scanning microscopy.

The group is very successful in attracting funding. In 2014 two prestigious personal grants were awarded to two group members: Dr. Chris P. Williams received a NWO VIDI grant and Dr. Këvin Knoops a NWO VENI grant.




Laatst gewijzigd:04 april 2017 10:10