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University Medical Center Groningen

Staff

Cleo van Diemen, PhD

Cleo van Diemen, PhD

Study: Biology at Leiden University

PhD thesis: Genetics of lung function decline and COPD development, 2008, University of Groningen

Email

See all my papers in PubMed, Google Scholar

Keywords

5GPM, next generation sequencing, genetic diagnostics, genetic association, epidemiology, inflammatory disorders

Research

For my PhD at the Dept. of Epidemiology, University of Groningen, I studied the genetics of lung function decline and the development of chronic obstructive pulmonary disease (COPD) in different populations, including prospective cohorts of the general population, a genetically isolated population, and two patient cohorts with different stages of COPD. After my PhD, I joined the group of Prof. Cisca Wijmenga in the Dept. of Genetics, UMCG, as a postdoc. I have worked on genetic risk models for celiac disease, performed functional genomics studies, including gene expression studies in patients with inflammatory bowel disease (IBD), and performed high-throughput sequencing studies to identify causal variants in genes associated to multiple immune-related diseases. In 2010, I was awarded an NWO Horizon grant for a project entitled, “Identifying biomarkers for immune-related diseases using genome-wide ribosomal-associated RNA expression profiles”.

Since 2013 I have been working as a staff member in the Development and Innovation section, headed by Rolf Sijmons, and my research has been focused on implementing new genetic tools into clinical practice. One of my major projects has been the implementation of rapid whole genome sequencing of critically ill newborns (the 5GPM or Five genes per minute project). Other current projects that I am working on are implementing RNA sequencing as a diagnostic tool in clinical practice and studying the role of mutations in noncoding DNA in monogenic diseases. In addition, I continue to work on the genetics of non-smoking COPD in collaboration with the departments of Epidemiology and Lung diseases of the UMCG and the department of Genetic Epidemiology of the Erasmus MC via a consortium grant from the Dutch Lung Foundation (Longfonds).

Selected publications

Laatst gewijzigd:20 maart 2017 10:46