Recent PhD theses
Theses from 2014 onwards. For earlier theses see here.
Supervisors in italics belong to the Dept of Genetics, UMCG
2023
Arrhythmogenic cardiomyopathy - beyond monogenetic disease
Edgar Hoorntje
Supervisors: Peter van Tintelen, Prof. M.P. van den Berg
Co-supervisor: Dr. J.D.H. Jongbloed
28 November 2023
Fine-mapping variants and genes that contribute to celiac disease
Roeland Broekema
Supervisors: Dr. Iris Jonkers, Dr. Sebo Withoff
20 November 2023
Using population biobanks to understand complex traits, rare diseases, and their shared genetic architecture
Esteban Lopera Maya
Supervisors: Prof. Sasha Zhernikova, Prof. Cisca Wijmenga
Co-supervisors: Dr. Serena Sanna, Dr. Patrick Deelen
22 May 2023
Increasing the molecular diagnostic yield in genetic diseases using spinocerebellar ataxia (SCA) as a disease model
Fatemah Ghorbani
Promotor: Prof. Dineke Verbeek
Co-promotors: Dr. Cleo van Diemen, Dr. Helga Westers
20 April 2023
Towards the genome clinic of the future - new computational methods to interpret genome variation and diseases
Shuang Li
Supervisors: Prof. Morris Swertz
Co-supervisors: Dr. Joeri van der Velde, Dr. Harm-Jan Westra
15 March 2023
Constructing medical test results: the social shaping of genetic results and their (un)certainty
Julia el Mecky
Supervisors: Prof. Irene van Langen, Prof. A.M. Lucassen
Co-supervisors: Dr. Mirjam Plantinga, Dr. K. Lyle
8 March 2023
Decision making, outcomes and result disclosure in the field surrounding genetic counselling
Jan Voorwinden
Supervisors: Prof. Adelita Ranchor, Prof. Irene van Langen
15 February 2023
2022
Context matters: The power of single-cell analyses in identifying context-dependent effects on gene expression in blood immune cells
Dylan de Vries
Supervisors: Prof. Lude Franke, Prof. Cisca Wijmenga
Co-supervisor: Dr. Monique van der Wijst
14 December 2022
Underexposed features of CHARGE syndrome: immunological, adrenal, and scapular function
Monica Wong
Supervisor: Prof. Conny van Ravenswaaij-Arts
Co-supervisors: Dr. E.H. Scholvinck, Dr. G. Bocca
9 November 2022
A stew of mixed ingredients: observational omics in the post-GWAS era
Olivier Bakker, graduated cum laude
Supervisor: Prof. Sebo Withoff
Co-supervisors: Dr. Iris Withoff, Dr. Yang Li
28 September 2022
Diagnostic applications of Next-Generation Sequencing
Mohamed Alimohamed
Supervisor: Prof. Rolf Sijmons
Co-supervisors: Dr. Birgit Raddatz, Dr. Helga Westers
1 June 2022
Molecular genetics of monogenic movement disorders: making meaning of rare variants
Kai Yu Ma
Supervisors: Dr. Dineke Verbeek, Prof. Teus van Laar
30 May 2022
Genetic determinants of human phenotypes: understanding human infectious diseases by computational biology methods
Zhenhua Zhang
Supervisors: Prof. Morris Swertz, Prof. Yang Li
Co-supervisor: Dr. Joeri van der Velde
28 April 2022
Observational causality from -omics
Adriaan van der Graaf
Supervisors: Prof. Lude Franke, Prof. Cisca Wijmenga
Co-supervisor: Dr. Serena Sanna
19 January 2022
2021
Multi-omics integration to understand immune system
Xiaojing Chu
Supervisors: Dr. Sebo Withoff, Dr. Yang Li
3 November 2021
Understanding the complexity of inflammatory bowel disease from a multi-omics perspective
Shixian Hu
Supervisors: Prof. Rinse Weersma, Prof. Jingyuan Yang-Fu
Co-supervisor: Dr. Arnau Vich Vila
1 November 2021
Ataxia and dystonia: from individual genes to networks and disease mechanisms
Miaozhen Huang
Supervisors: Dr. Dineke Verbeek, Prof. M.A.J. de Koning-Tijssen
25 October 2021
Genetic regulation of gene expression in brain and blood
Niek de Klein
Supervisors: Prof. Lude Franke, Prof. Cisca Wijmenga
13 September 2021
Implementing Population-based Expanded Carrier Screening Reporting Couple Results Only: A Mixed Methods Approach
Juliëtte Schuurmans
Supervisors: Prof. Irene van Langen, Prof. Anneke Lucassen, Prof. Adelita Ranchor
Co-supervisor: Dr. Mirjam Plantinga
28 June 2021
Environment-host-microbe interactions shape human metabolism
Lianmin Chen, graduated cum laude
Supevisors: Prof. Jingyuan Yang-Fu, Prof. Folkert Kuipers, Prof. Alexandra Zhernakova
22 June 2021
2020
Core gene identification using gene expression
Annique Claringbould
Supervisors: Prof Lude Franke, Prof Cisca Wijmenga
2 December 2020
Celiac disease: from genetic variation to molecular culprits
Maria Zorro
Supervisors: Prof Cisca Wijmenga, Dr Sebo Withoff, Dr Iris Jonkers
22 April 2020
2019
Understanding the gut ecosystem: bugs, drugs & diseases
Arnau Vich Vila, graduated cum laude
Supervisors: Rinse Weersma, Sasha Zhernakova
2 December 2019
Genomic heterogeneity of clear cell renal cell carcinoma
Paranita Ferronika
Supervisor: Rolf Sijmons. Co-supervisors: Klaas Kok, Helga Westers.
26 November 2019
Genetic susceptibility for inflammatory bowel disease across ethnicities and diseases
Suzanne van Sommeren
Supervisors: Rinse Weersma and Cisca Wijmenga
25 November 2019
Next Generation Sequencing Guided Molecular Diagnostic Tests in Non-small-cell Lung Cancer
Jiacong Wei
Supervisors: Anke van den Berg and Harry Groen. Co-supervisor: Klaas Kok
19 November 2019
Functional genomics approach to understanding sepsis heterogeneity
Kieu Le
Supervisors: Cisca Wijmenga. Co-supervisors: Jill Moser andVinod Magadi Gopalaiah
16 October 2019
Paediatric cardiomyopathies – An evolving landscape of genetic etiology and diagnostic applications
Anne Herkert
Supervisors: Irene van Langen, M.P. van den Berg. Co-supervisor: J.D.H. Jongbloed
16 October 2019
Integrative omics to understand human immune variation
Raúl Aguirre-Gamboa
Supervisors: Cisca Wijmenga. Co-supervisor: Yang Li
14 October 2019
Looking through the noise – Novel algorithms for genetic variant detection
Lennart Johansson
Supervisors: Rolf Sijmons, Morris Swertz. Co-supervisor: Birgit Sikkema-Raddatz
25 September 2019
Young-onset movement disorders – g enetic advances require a new clinical approach
Maartje van Egmond
Supervisor: Marina de Koning-Tijssen. Co-supervisor: Tom de Koning
3 July 2019
Towards finding and understanding the missing heritability of immune-mediated diseases
Isis Ricaño Ponce
Supervisor: Cisca Wijmenga. Co-supervisor: Vinod Magadi Gopalaiah
3 June 2019
Decoding non-coding RNAs in fatty liver disease
Biljana Atanasovska
Supervisors: Jingyuan Yang-Fu and Cisca Wijmenga
20 May 2019
The gut microbiome in intestinal diseases
Floris Imhann , graduated cum laude
Supervisors: Rinse Weersma and Cisca Wijmenga
15 May 2019
Multi-omics strategies for detecting gene-environment interactions
Patrick Deelen
Supervisors: Morris Swertz, Lude Franke and Cisca Wijmenga
6 May 2019
A systems genomics approach to identify risk loci and pathways to Candida infection
Vicky Matzaraki
Supervisor: Cisca Wijmenga. Co-supervisor: Vinod Magadi Gopalaiah
6 March 2019
Towards personalised treatment of patients with colorectal liver metastases
Joost Hof
Supervisors: Rolf Sijmons, K.P. de Jong. Co-supervisor: Klaas Kok
27 Febrary 2019
2018
Genotyping and phenotyping epilepsies of childhood
Danique Vlaskamp
Supervisors: Conny van Ravenswaaij-Aarts, Oebo Brower
5 December 2018
Inflammatory Bowel Disease: 'New genes, rare variants & moving towards clinical practice'
Marijn Visschedijk
Supervisors: Rinse Weersma, Cisca Wijmenga
5 September 2018
Integration techniques for modern bioinformatics workflows
Alex Kanterakis
Supervisors: Morris Swertz, Cisca Wijmenga
11 July 2018
Young-onset movement disorders. Genetic advances require a new clinical approach
Martje E. van Egmond
Supervisors: MAJ de Koning-Tijssen, Tom J de Koning
TBA
Computational methods for data discovery, harmonization and integration
Chao Pang
Supervisors: Morris Swertz, JL Hillege
3 July 2018
Exon skipping therapy for dystrophic epidermolysis bullosa
Jeroen Bremer
Supervisor: MF Jonkman, Co-supervisors: AMG Pasmooij, Peter van den Akker
25 April 2018
Gene expression studies. From basic research to the clinic
Juha M. Karjalainen
Supervisors: Cisca Wijmenga, Lude Franke
15 January 2018
Translational software infrastructure for medical genetics
K. Joeri van der Velde
Supervisors: Morris Swertz, Richard Sinke, Co-supervisor: Yang Li
8 January 2018
2017
CHARGE syndrome:
CHD7
mutations, heart defects and overlapping syndromes
Nicole Corsten-Janssen
Supervisors: Conny van Ravenswaaij
11 October 2017
The genetics of spinocerebellar ataxia and dystonia
Esther AR Nibbeling
Supervisors: Dineke Verbeek, Richard Sinke, M.A. de Koning-Tijssen; Co-supervisors: Conny van Ravenswaaij, F Baas, HPH Kremer
29 March 2017
The interplay between genetics, the microbiome, DNA-methylation & gene‐expression
Marc Jan Bonder, graduated cum laude
Supervisors: Cisca Wijmenga, Lude Franke; Co-supervisor: Alexandra Zhernakova
22 March 2017
2016
supervisors in italics belong to the Dept of Genetics, UMCG
From bugs to buttermilk: epidemiological and molecular aspects of gut health
Ettje F. Tigchelaar-Feenstra
Supervisors: Cisca Wijmenga, EJM Feskens
14 December 2016
SETD2 and PBRM1 inactivation in the development of clear cell renal cell carcinoma
Jun Li
Supervisors: Rolf Sijmons, JHM van den Berg, Co-supervisors: Klaas Kok, Helga Westers, JL Kluiver
28 September 2016
Multi-omics approaches for better understanding of the downstream effects of genetic risk factors
Daria Zhernakova
Supervisors: Lude Franke, Cisca Wijmenga
12 September 2016
Genetics of Hirschsprung disease. Rare variants, in vivo analysis and expression profiling
Duco Schriemer, Departments of Genetics and of Neuroscience, UMCG
Supervisor: Robert Hofstra (now at Erasmus MC); Co-supervisor: BJL Eggen
20 June 2016
Unravelling the genetic basis of hereditary disorders by high-throughput exome sequencing strategies
Omid Jazayeri
Supervisor: Richard Sinke, Co-supervisor: Behrooz Alizadeh
20 June 2016
Enhancing genetic discoveries with population-specific reference panels
Serena Sanna (external PhD candidate from Institute of Biomedical and Genetic Research, Cagliari, Italy)
Supervisors: Cisca Wijmenga, Lude Franke
9 May 2016
Data quality and methodology in studies on maternal medication use in relation to congenital anomalies
Linda de Jonge
Supervisors: Irene van Langen, Lolkje de Jong-van den Berg, Marian Bakker
2 March 2016
The molecular neuropathology of spinocerebellar ataxia type 23
Cleo Smeets
Supervisor: Richard Sinke, Co-supervisor: Dineke Verbeek
2 March 2016
2015
Introducing eHealth and other innovative options into clinical genetic patient care in view of increased efficiency and maintenance of quality of care: patients' and providers' perspectives
Ellen Otten
Supervisors: Irene van Langen, AV Ranchor, E Birnie
7 December 2015
HLA and other tales: The different perspectives of Celiac Disease
Javier Gutierrez Achury
Supervisors: Cisca Wijmenga, Alexandra (Sasha) Zhernakova
Now a postdoc with Carl Andersen, at Sanger Centre, Cambridge, UK (more about Javier Gutierrez Achury)
2 December 2015
Finding the missing 'LiNCs' in celiac disease
Barbara Hrdličková
Supervisor: C Wijmenga, Co-supervisors: S Withoff, V Kumar
11 May 2015, full text of thesis
Matters of the heart: genetic and molecular characterisation of cardiomyopathies
Anna Pósafalvi, PharmD
Supervisor: RJ Sinke, Co-supervisor: JDH Jongbloed
20 April 2015, full text of thesis
Beyond genome wide association studies in celiac disease by exploring the non-coding genome
Rodrigo Coutinho de Almeida
Supervisor: C Wijmenga, Co-supervisor: S Withoff
25 March 2015, full text
Genetic etiology of type 2 diabetes. From gene identification to functional genomics
MR (Mike) Erdos, Senior Staff Scientist in the Collins laboratory at the National Center for Human Genome Research, NIH (Bethesda, USA) in cooperation with Dept of Genetics, UMCG
Supervisors: C Wijmenga, MH Hofker, FS Collins
18 March 2015, full text
Health of children born to subfertile couples : aetiological pathways and neurodevelopmental correlates
Jorien Seggers
Supervisors: M Hadders-Algra, MJ Heineman Co-supervisor: ML Haadsma
16 February 2015, full text
Medullary Thyroid Carcinoma. From diagnosis to treatment
HHG (Hans) Verbeek, MD
Supervisors: TP Links, JTM Plukker, RMW Hofstra
7 January 2015, full text
2014
supervisors in italics belong to the Dept of Genetics, UMCG
Genetic origin of Dupuytren’s disease and associated fibromatosis
GHCG (Guido) Dolmans MD
Supervisors: PMN Werker, C Wijmenga
24 November 2014, full text of thesis
Interpreting disease genetics using functional genomics
Harm-Jan Westra, graduated cum laude
Supervisors: L Franke, C Wijmenga
17 September 2014, full text
Congenital heart defects and pulmonary arterial hypertension. Genes, environment and heredity
WS (Mieke) Kerstjens-Frederikse
Supervisors: RMW Hofstra, RMF Berger
2 July 2014, full text
Inflammatory bowel disease: the genetic background and beyond
Karin Fransen
Supervisors: C Wijmenga, RK Weersma, Co-supervisor: CC van Diemen
16 June 2014, full text
Marfan syndrome and related connective tissue disorders: cardiologic and genetic aspects
Jan JJ Aalberts
Supervisors: IM van Langen, MP van den Berg, Co-supervisor: JP van Tintelen
23 April 2014, full text
Inherited cardiomyopathies. Genetics and gene-environment interactions
Karin van Spaendonck
Supervisors: IM van Langen, MP van den Berg, Co-supervisor: JP van Tintelen
5 March 2014, full text of thesis
Understanding the origin of congenital heart disease
Maria Eline (Marlies) Smilde-Baardman
Supervisors: RMW Hofstra, RMF Berger, Co-supervisors: MK Bakker, T. Plosch
5 February 2014, full text
| Laatst gewijzigd: | 30 november 2023 11:33 |