Program Antibiotics-Now!

PrFont34Bin0BinSub0Frac0Def1Margin0Margin0Jc1Indent1440Lim0Lim1Program Antibiotics - Now!

Zernike campus, Bernouilliborg, Groningen

May 2nd, 2016

10.30        Oscar Kuipers (chair)        Welcome

10.40        Edith Schippers        Video message on Dutch initiatives

10.45        Sally Davies        A ticking time bomb: The threat of

               antimicrobial resistance

1st session: The resistance problem and why don't we have new drugs?

Chair: Christina Vandenbroucke Grauls

11.15        Dirk Brockmann (Berlin)                Measuring the networks that matter in disease dynamics

11.45        Willem van Schaik (Utrecht)                Antibiotic resistance and the human microbiome?

12.15        Heike Brötz-Oesterhelt (Tuebingen)                Past and present strategies in antibiotic drug discovery

12.45-14.00 Lunch

2nd session: How to open up the pipeline

Chair: Nathaniel Martin

14.00        Floris Rutjes (Nijmegen)                Early stage discovery of small molecule antibiotics

14.30        Rainer Fischer (Aachen)                Facilitating drug development

15.00        Christina Vandenbroucke-Grauls        Drugs and resistance: something old (Amsterdam)        and something new

15.30-16.00 Coffee break

3rd session: New leads from the lab

Chair: Jan Willem Veening

16:00        Arnold Driessen (Groningen)                Filamentous fungi as resource and production host for bioactive compounds

16:30        Oscar Kuipers (Groningen)                Novel antimicrobials by synthetic biology

17.00        Nathaniel Martin (Utrecht)                New antibiotic strategies: targeting the

                       lipid II pathway from start to finish

17:30        Jasper Knoester (Groningen)

17.50-18.30 Drinks and snacks

May 3rd, 2016

4th session: New candidates from Nature

Chair: Oscar Kuipers

9.00        Anna Vagstad (Zurich)                Proteusin peptide natural products, an expanding repertoire of post-translational modifications

9.30        Gilles van Wezel (Leiden)                Biological insights as basis for the discovery of novel antibiotics

10.00        Bob Hancock (Vancouver)                Alternatives to antibiotics - new approaches to treating recalcitrant infections

10.30-11.00 Coffee break

5th session: Synthesis and modification of antibiotics

Chair: Gilles van Wezel

11.00        Ben Feringa (Groningen)                Photopharmacology, light on antibiotics

11.30        Florian Kloss (Leibnitz)                Neglected bacteria as prolific sources of unprecedented antibiotic scaffolds

12.00        Adri Minnaard (Groningen)                Antibiotics against Mycobacterium tuberculosis

12.30-13.30 Lunch

6th session: Other viewpoints

Chair: Alex Friedrich

13.30        Henri Verbrugh (Rotterdam)                Phage therapy, now or never…?

14.00        Maite Muniesa Perez (Barcelona)                Phage-related horizontal transfer of resistance

14.30        Jan van Hest (Nijmegen)                Novel approaches to targeted drug delivery

15.00- 15.30 Coffee break

7th session: The whole chain

Chair: Jos van der Meer

15.30        Ursula Theuretzbacher (Vienna)                New economic models for antibiotic R&D

16.00        Bhanu Sinha (Groningen)                An integrated view of the entire chain for development

16.30        Jos van der Meer (Nijmegen)                Closing remarks

16.45 End

Contact: Antibiotics-now@rug.nl

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