Structure-Function Relationships of Proteins

Structure-function relationships of proteins and biomolecules are determined via the high resolution analysis of structures and active sites of enzymes and larger protein complexes, utilizing various biophysical approaches such as protein X-ray crystallography, NMR, cryo-electron microscopy, and molecular dynamics in combination with other (single molecule) biochemical and biophysical tools. Biomolecules under investigation are (secundary) metabolites, carbohydrates and proteins. For the latter focus is on natively unfolded proteins, biocatalytic enzymes involved in carbohydrate bioprocessing and biotransformation of synthetic compounds, transporters and membrane membrane protein complexes, proteins involved in photosynthesis, and proteins involved in host invasion and virulence.

Principal GBB scientists

Prof.dr. E.J. Boekema, Dr. A.H.M.W. Thunnissen, Dr. A. Terwisscha van Scheltinga, Prof.dr. A.J.M. Driessen, Dr. J. Broos, Prof.dr. D.B. Janssen, Prof.dr. M.W. Fraaije, Prof.dr. B. Poolman, Prof.dr. D.J. Slotboom, Prof.dr. L. Dijkhuizen, Prof.dr. J.P. Kamerling, Dr. G. Oostergetel, Prof.dr. S.J. Marrink, Dr. A.H. de Vries.