The Systems Biology Biology Centre for Metabolism and Ageing
Our goal: to unravel the intricate relationship between metabolism and the biology of ageing. This relationship, which has been conserved throughout evolution, is bidirectional: metabolism affects the ageing of an organism, while the metabolic system itself declines under the influence of ageing.
Both metabolism and ageing are systems properties that are affected by a large number of processes at the molecular, cellular and organ level. Hence a full understanding of metabolism, ageing and their interaction necessitates a systems-biology approach.
We use the budding yeast Saccharomyces cerevisiae and the mouse as model organisms.
With an interdisciplinary team of scientists,we will use various approaches of systems biology.
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Approaches :
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High-throughput omics techniques
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Dedicated quantitative experimentation
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Top-down computational approaches
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Bottom-up modeling approaches.
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